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Intracellular carnitine concentration is much higher than extracellular concentration which is achieved by this plasma membrane sodium carnitine co-transporter with ATPase activity (Figure 1)

Pairing L-Carnitine with lifestyle habits L-Carnitine works best when paired with supportive daily habits, including: eating protein regularly staying hydrated engaging in regular physical activity prioritizing sleep and stress management These habits allow the body to utilize L-Carnitine efficiently while also supporting metabolism and overall wellness

It also serves as a substrate for various antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which further amplify its protective effects

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46 Both SIRT1 and SIRT6 are found to be downregulated in older skin, and this correlates with a reduction in available NAD+