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DNA methylation in the core promoter region of SIX1 gene in muscle tissues was potentially regulated by histone H4 and E2F2 and shown to impact muscle development in Qinchuan cattle (Wei et al., 2018)

According to this hypothesis, heterogeneity and hierarchy among all of the cells exist as a consequence of asymmetric division of cancer stem cells (CSCs) within the tumor mass, and all other cells comprising the tumor bulk are the result of differentiated CSCs [2]

While some findings are intriguing, they are far from conclusive, especially when it comes to human use

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Sanaeifar F, Pourranjbar S, Pourranjbar M, Ramezani S, Mehr SR, Wadan A-HS et al (2024) Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration