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These extracts caused DNA nicks, apoptosis, and cell cycle arrest in a dose- and time-dependent manner by increasing the production of reactive oxygen species (ROS) and lowering mitochondrial potential [93] possibly by blocking the Protein Kinase C (PKC) [94]
When used as a treatment, Glutathione works to lighten pigmentation, reduce melanin production, and promote an even-toned complexion
pmid:31044583 Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE (2003) Inhibition of -ketoglutarate dehydrogenase complex promotes cytochrome C release from mitochondria, caspase-3 activation, and necrotic cell death
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The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism
