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Alcohol at higher intake levels is associated with liver disease, several cancers including colorectal and liver cancer, cardiovascular disease, high blood pressure, depression, cognitive decline, impaired sleep, reduced testosterone, and reduced fertility

Desaturation and elongation of essential fatty acids The figure shows two vertical pathways of the metabolism of essential fatty acids, illustrating conversion to long-chain polyunsaturated fatty acids through desaturation (addition of a double bond) and elongation (addition of two carbon atoms) reactions: Omega-6 fatty acid pathway: At the top, linoleic acid (18:2n-6) is stepwise converted to 18:3n-6, then to 20:3n-6, then to 20:4n-6 (arachidonic acid), followed by conversion to 22:4n-6, 24:4n-6, 24:5n-6, and finally 22:5n-6

10.1016/j.cmet.2012.12.012 Cell Metab

I., Wu, Y., Mishra, D., Donnelly, R

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