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Nat Rev Urol 21 , 6790 (2024)

Nociceptive pain arises from the activation of highthreshold peripheral sensory neurons, known as nociceptors, in response to intense mechanical, chemical, or thermal noxious stimuli that typically subsides once the noxious stimulus is removed

In addition to the effects described, xenobiotic toxicants bound to PM can elicit a range of additional health impacts by amplifying the toxicological burden on the respiratory system, for example, interference with cellular signaling pathways through heavy metal compounds, impairing the repair mechanisms of lung tissue and promoting chronic inflammation [204]

The device was evaluated ex vivo using euthanized mouse skin [Figure 7D]