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The analysis was performed on a C18 column (YMC-Pack Pro C18, 250 X 4.6, S-5 m, 12 nm) under reversed-phase partition chromatographic conditions
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Upon activation by ligand binding, AhR is released from the translocation inhibitory complex (formed by chaperone proteins HSP90 and XAP2) which reveals AhRs nuclear localization signal (NLS)
