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However, some changes, like abnormal DNA methylation in genes critical for hepatocyte differentiation, may be irreversible, potentially leading to long-term liver dysfunction

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doi: 10.1111/vop.12679

This joint comprises ligaments that connect the bone on the sole of the foot, below the big toe/proximal phalanx, to the bones that connect the toes to the larger bones in the feet/metatarsals

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