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Early studies identified notable hypermethylation in genes related to calcium dynamics, oxidative stress, and synaptic function, predominantly in non-promoter regions such as introns and cryptic areas

[DOI] [PubMed] [Google Scholar] 82.Whitehall V.L.J., Dumenil T.D., McKeone D.M., Bond C.E., Bettington M.L., Buttenshaw R.L., Bowdler L., Montgomery G.W., Wockner L.F., Leggett B.A

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This enhancement was achieved by downregulating the mRNA and protein levels of P-gp and ABCG2, demonstrated in both in vitro and in vivo models of CRC using HCT8 and SW480 cells (Zhang et al., 2018)