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doi: 10.1161/CIRCRESAHA.116.304937 92 MaT.WangY

37 Furthermore, even if CRF application protects against gastric ulcers, 38 exogenous administration of CRF can reproduce cardinal features of diarrhea predominant irritable bowel syndrome including anxiogenic behavior, enhanced visceral pain to colorectal distention, increased colonic mucus secretion, propulsive motility, development of watery stool/diarrhea, and increased colonic mucosal permeability facilitating bacterial translocation into colonic tissue

Their presence in natural water cycles represent a risk to human health and the ecosystem

doi: 10.1681/ASN.2008101090 36 Kurella TamuraMYaffeKHsuCYYangJSozioSFischerMet al
