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Only the loci that exhibited statistically significant differences between the compared groups were chosen for further analysis

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The pretreatment of cells with GHK-Cu significantly reduced LPS-induced ROS production

The alanine replacement of L99 2.62 did not affect the G s signaling, however, M121 3.32 A almost abolished the G s signaling and the L356 7.39 A mutant suffered an over 10-fold potency reduction and 50% decrease in the maximum level of cAMP production