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Lancet 377:19291937 Creager MA, Olin JW, Belch JJ, Moneta GL, Henry TD, Rajagopalan S, Annex BH, Hiatt WR (2011) Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication

Common symptoms associated with chronic inflammation include: Joint pain and stiffness Muscle soreness Digestive discomfort Fatigue Slower recovery after exercise Reduced mobility Ongoing soft tissue irritation Because inflammation can affect multiple systems throughout the body, many people look for solutions that support healing rather than simply masking symptoms

At the same time, insulin modulation becomes more dysregulated at this stage due to irregular and unstable blood sugar levels associated with metabolic syndrome if it is present

10.1016/j.coph.2007.04.004 [DOI] [PubMed] [Google Scholar] Ren D., Villeneuve N.F., Jiang T., Wu T., Lau A., Toppin H.A., and Zhang D.D

Important caveats Large-scale, long-term human outcome data are limited
