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NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT

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Discovering the false discovery rate

Furthermore, a negative association of IGF-1 with CC-IMT was observed only in patients with low vitamin D levels (152) and was supported by findings of a comparative study of obese individuals and healthy controls showing that IGF-1 protects against CC-IMT when serum vitamin D levels are low (154)