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Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress

10.1159/000342171 102 LutzH

J Agric Food Chem 66:31463154

In addition, thiamine has been shown to reverse oxidative stress pathology in conditions that are not caused by TD [69]

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