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The mitochondrial heat shock proteins belonging to the chaperonin family, Hspd1 (Hsp60) and Hspe1 (Hsp10), both promote the proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix 38

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Previous studies showed that unsaturated lipid peroxidation-derived aldehydes such as 4-HNE triggered autophagy in a JNK-dependent manner by activating the endoplasmic reticulum stress (ER) response