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Drafting the manuscript: YS, ZW, QW, LK, and QY

Conversely, in a previous study on extensive-stage SCLC, the addition of HCQ to platinum-based chemotherapy failed to improve overall survival and even increased toxicity (84), underscoring that HCQ is not a universal agent and thus necessitates careful patient stratification

The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl

Clinical studies show NR supplements can boost NAD+ by 142% after eight weeks of daily 1000 mg doses

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