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The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation
Among the mechanisms envisaged to occur to explain their toxicity against cells in culture are the release of toxic cadmium ions through their dissolution by the acidic environment of cell lysosomes [195] and their ability to generate and trap free radicals [196,197,198,199]
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This trend is particularly pronounced in males and infants with very low birth weight, implying that more targeted treatment interventions should be implemented early in BPD (82)
