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At that time, while the mechanism of action of PTX was not fully understood, it was known that PTX can block TGF-1-mediated inflammation, hinder type I collagen deposition, and act as a non-specific phosphodiesterase (PDE) inhibitor

10.1002/cmdc.200900319 [DOI] [PubMed] [Google Scholar] Prelog V., Oppolzer W

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