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Description
When taurine levels are low, bile acid conjugation shifts toward glycine conjugation, which produces less efficient bile salt micelles and impairs toxin excretion

The most clinically significant GPX1 variant is Pro198Leu (rs1050450) a CT transversion in codon 198 that substitutes leucine for proline in the GPX1 protein

Urinary Changes : Urine that appears dark in color is a warning sign

Sorbitol-based osmotic diarrhea: possible causes and mechanism of action

However, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage
