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Because a high percentage of people have genetic differences that inhibit the activation of B vitamins (called MTHFR genetic mutations), the best versions of these vitamins to take are the already-activated, "methylated" forms: methylfolate, methylcobalamin, hydroxy- or hydroxocobalamin, or adenosylcobalamin

Additionally, double-stranded RNA-activated protein kinase (PKR) has been identified as a key transducer of inflammatory signals in colonic epithelial cells

Additionally, the authors discovered a potential new viral biomarker of metabolic syndrome, VC_818_0, a phage from Roseburia/Blautia bacteria belonging to the Candidatus Heliusviridae phage family

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(2) Increased substrate accessibility, and (3) inflexibility in metabolism changes