iv glutathione acetaminophen metabolism and production of toxic metabolite (Courtesy Management of paracetamol (acetaminophen) toxicity
Description
Molecular mechanisms of midfacial developmental defects
10.1074/jbc.M513192200 37 FergusonG

This mechanism is primarily associated with decreased expression of synaptic-related genes, abnormal development of dendritic spines, increased apoptosis, and reduced expression of PSD95 (327329)

As these break down over time, the lack of support causes the area beneath the eyes to sink and droop

10.1002/jmr.2170 55 GiulianiA
