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Among many, BRCA1 and BRCA2 are the most extensively studied tumor suppressor genes (TSGs) linked with repairing double-strand DNA (dsDNA) breaks via homologous recombination

Researchers are particularly interested in its ability to promote functional recovery even in challenging injury models

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It was found that verteporfin significantly decreased the expression of E-cadherin, N-cadherin, vimentin in UM-SCC6 spheroids induced by CAF-S2/S4 sEVs (Fig
