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The trial established the use of topical GHK-Cu in cosmetic dermatology and is among the most widely cited human clinical studies in the GHK-Cu literature

2 The Pathogenesis of IBD 2.1 Immune Cells 2.1.1 Macrophages As shown in Figure 1, macrophages are monocytes that may play a phagocytic function in immune regulation, and they play an essential role in the innate and specific immune response ( FIGURE 1 In contrast, to counteract the excessive inflammatory response at a later stage, macrophages can be converted from M1 to M2 phenotype to suppress inflammation protecting the host from extreme damage and promoting wound healing

doi: 10.1038/nature10167

In both studies, the authors found that concomitant ligamentous or meniscal pathology was present in ~70% of cases, corresponding to the high prevalence of traumatic etiology in these patients

and Hyaluronic Acid acts as a lubricant for smooth joint movement