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Under normal conditions, increased insulin release by pancreatic -cells is sufficient of insulin action and maintain normal glucose tolerance ( In addition, IR was independently associated with each of the chronic macrovascular and microvascular complications from diabetes ( 2.2 IR and tumor In recent years, a wealth of experimental, epidemiological and clinical evidence has suggested that IR and its compensatory hyperinsulinemia have a synergistic relationship with the development and progression of certain types of cancer, including breast, colorectal, prostate, pancreatic, adrenocortical and endometrial cancers ( via the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and Ras/MAPK pathways ( 2.3 IR and cardiovascular and cerebrovascular diseases IR is thought to be a key risk factor leading to cardiovascular and cerebrovascular diseases in different populations, whether normal or diabetic (4346)

15 Duke Regeneration Center, Duke University School of Medicine, Durham, North Carolina, USA

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