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A schematic illustration of the structure of ATP7B is presented in Figure 1

Glutathione is an antioxidant found in many sources, including plants, animals, and fungi

The traditional Chinese medicine compound JianpiHuayu Decoction has been shown to enhance NK cell cytotoxicity by suppressing TREM1/DAPI2 signaling in TAMs, thereby alleviating immunosuppression in the TME and synergizing with PD1 inhibitors in hepatocellular carcinoma [222]

Currently, it is challenging to provide definitive therapeutic recommendations because the understanding of how iron interacts individually with mitochondria, dopamine, and synapses, as well as how these three systems interplay in situations of iron dyshomeostasis, remains incomplete

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