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De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, et al

87 demonstrated that inhibition of the histone H3K4 methylation complex (composed of ASH-2, WDR-5 and SET-2) and overexpression of RBR-2, the enzyme that mediates H3K4 demethylation, resulted in lifespan extension

Statins: HMG-CoA reductase inhibitors are very commonly prescribed medications to lower serum LDL levels and reduce the risk of cardiovascular disease
