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Finally, succinate was shown to bind to SUCNR1 on tumour cells and suppress factors that facilitate T cell trafficking into to the tumour 69 , thereby reducing anti-PD1 efficacy, whereas in vitro succinate treatment of CAR T cells improved its effector function 61

Although the clinical application of vitamin C in myocardial infarction therapy is predominantly focused on the prevention of oxidative stress and inflammation, there are solid data supporting its expanding role across all phases of healing and remodeling after MI

doi: 10.3389/fendo.2021.735638 149 FontanaKCamposGERStaronRSda Cruz-HoflingMA

There are several possible reasons for this failure

Human hippocampal neurogenesis persists throughout aging