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Effert PJ, Bares R, Handt S, Wolff JM, Bull U, Jakse G

Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

Intense muscle activity (e.g., intense exercise, seizure)

Little is known about potential causes of CFS, though several recent studies point to activation of inflammatory cascades and issues with mitochondrial energy production (1520)

7:20 p.m.: This article was updated with new fire figures