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Most drug elimination pathways will become saturated if the dose and therefore the concentration are high enough

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The researchers established a 5-compound (5C) protocol, consisting of SB431542, forskolin, DAPT (Notch inhibitor), IWP2 (Wnt inhibitor), and LDN193189 (BMP inhibitor) to suppress the expression of epithelial to mesenchymal transition marker genes (Xiang et al., 2019)

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Two Faces of Neutrophils in Liver Disease Development and Progression