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Modulating the Microbiota as a Therapeutic Intervention for Type 2 Diabetes

Mitochondrial biogenesis is mediated by peroxisome proliferator-activated receptor coactivator-1 (PGC-1) under the control of the histone deacetylase sirtuin 1 (SIRT1) 32 which has emerged as a crucial regulator of mitochondrial function in vascular smooth muscle 33 , liver 34 , kidney 35,36,37 , and heart 38,39

Moreover, in rabbit lenses ex vivo, treatment with chlorogenic acid prevented lens opacity induced by hydrogen peroxide in a dose-dependent manner [90]