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Key characteristics of alpha arbutin include: Gradual brightening Minimal irritation Suitable for sensitive skin Safe for long-term use Works well with niacinamide, vitamin C, and sunscreen Because alpha arbutin works slowly, patience is requiredbut the results are more stable and natural-looking

Further animal testing may be required for those test articles which are identified as genotoxic in the in vitro assays

The combination also appears to reduce injection site reactions, making the practical experience more comfortable

Informed Consent Statement Informed consent was obtained from all subjects involved in this study

doi: 10.1016/0006-2952(79)90060-1