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Description
No Tolerable Upper Level has been set for B12 in the UK due to its low toxicity, though serious adverse reactions, while rare, are possible

In this study, B12 levels were 244 pmol/l or more in all patients at baseline, but in those who improved, B12 levels almost quadrupled, whilst in non-responders B12 levels went up by only 50%

Copper Ion (Cu)

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This is precisely why the titration schedule exists
