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This acquired disease develops due to degeneration of the pigmentary photoreceptor-retinal epithelial cell layer, Bruch's membrane, and chorio-capillaries complex [71,72]

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Caspases, which are cysteine-dependent aspartate-directed proteases regulated by Bcl-2 family proteins, heat shock proteins, and apoptosis inhibitors, become active in the cytosol upon activation and then cleave a wide range of proteins, are common features of the diverse routes leading to apoptosis ( Fig