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Cancer-pathway concern IGF-1 signaling is mitogenic and anti-apoptotic, two properties relevant to cancer biology

Common, mild effects: Temporary soreness, redness, or irritation at the injection site

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The single human dataset for musculoskeletal use is a retrospective chart review of sixteen knee-pain patients who paid for intra-articular injections, with subjective improvement reported in fourteen and no control, no blinded assessment, and no objective imaging endpoint

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Matek D., Matek I., Staresinic E., Japjec M., Bojanic I., Boban Blagaic A., Beketic Oreskovic L., Oreskovic I., Ziger T., Novinscak T., et al