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doi: 10.1038/nn.4113 26 MenardCPfauMLHodesGEKanaVWangVXBouchardSet al

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Consequently, pharmacological metformin concentrations increased mitochondrial oxidative phosphorylation in liver cells [76,77] and promoted mitochondrial fission through the phosphorylation of mitochondrial fission factor and the recruitment of dynamin-related protein 1 (DRP1) by AMPK [76,78]