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doi: 10.1038/nature07228 [DOI] [PubMed] [Google Scholar] 90
Therefore, in patients with renal or hepatic insufficiency (or both), arginine is generally avoided or only administered with extreme caution under close monitoring

Conversely, in another study, 615 patients with IGF-1 values in the lower half of the normal range were closely observed during 4.5 years

Journal of Clinical Oncology 2014;32:41206

Strong safety record across clinical reviews