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The third line of antioxidant defence is an adaptive and regulatory function and consists of enzymes, present in the cytosol of cells and mitochondria, that remove oxidised biomolecules through a variety of oxidantinduced enzyme systems (DNA repairs enzymes, lipases, proteases, transferases and methioninesulfoxide reductases)
Nat Immunol 22:1107
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Bjorklund T, Hall H, Breysse N, Soneson C, Carlsson T, Mandel RJ et al (2009)
Interestingly, despite the significant reduction in total parent estrogen (E2 + E1) levels in the COC users, the total hormone and metabolite excretion levels were not lower
