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Independent-control format

Given that diarrhea and not endotoxemia is one of the principal clinical consequences of infection with enteric toxigenic bacteria, which demonstrably affect tight junction function, one must differentiate the modest increase in paracellular permeability reported in inflammatory conditions with no known over acute clinical consequences from the marked increase in paracellular permeability induced by enteric exotoxins with consequent massive fluid and electrolyte secretion and diarrhea

PubMed McGuire F, Hughes E, Maak T, Cushman DM Thymosin Beta-4 and TB-500 in Tissue Healing, Regeneration, and Musculoskeletal Repair: A Scoping Review

Its origin in gastric juice gives it unique stability in the GI tract, making it effective both orally and by injection

The choice between them for glycemic control alone would likely favor tirzepatide simply because it is available and proven, while retatrutide remains investigational