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Loren Pickart isolated it from human plasma albumin at the Cardiovascular Research Institute

de Toledo-Morrell L, Goncharova I, Dickerson B, Wilson RS, Bennett DA

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This decline contributes to thinner skin, reduced bone density, increased visceral fat, and slower recovery from injury (Rudman et al., N Engl J Med 1990)

They bind to specific receptors on cell surfaces and trigger targeted biological responses
