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Responses of gut microbiota to diet composition and weight loss in lean and obese mice (in Eng)
These animals are fed a high-fat diet until they become obese, then randomized to receive either 5-amino-1mq or a control treatment
5-Amino-1MQ's mechanism centers on NNMT inhibition: NNMT inhibition : Selectively blocks NNMT with an IC50 of approximately 1.2 microM
