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By inhibiting this enzyme, A1AT decreases the production of superoxides, contributing to a reduction in the overall ROS burden in tissues and helping to limit oxidative damage ( Furthermore, A1AT binds to metal ions such as copper (Cu) and iron (Fe), which catalyze ROS production via the Haber-Weiss and Fenton reactions

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This work has been funded by the German Research Foundation (DFG) through grant LE LE2905/1-2 to LIL as part of the priority program 1710 Dynamics of Thiol-based Redox Switches in Cellular Physiology