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Description
Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604
It happens as a result of damage to the trigeminal nerve, which carries sensations from the face to the brain
When GLP-1R agonists penetrate the blood-brain barrier and reach this region, they can trigger nausea signals
No medical claims.
Day 2: Santa Rosa Marampata We start to descend for approximately one hour to La Playa Rosalina (1500 m.a.s.l.)
