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In the polyol pathway, glucose is converted to sorbitol by the enzyme aldose reductase (AR)a reaction that depends on the donation of an electron from the cofactor NADPH which then becomes NADP + (Figure 4)

10.1182/blood.2020007233 123 StelmachP.TrumppA

Despite the efficacy of current antiepileptic drugs, almost 30% of patients with epilepsy are refractory to medical treatment, have progressive cognitive impairment, and require neurosurgical resection of the epileptic tissue to ameliorate recurring seizures (Laxer et al., 2014)

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In addition, the body's own substance is involved in human wound healing