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Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFR
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Masic U, Harrold JA, Christiansen P, Cuthbertson DJ, Hardman CA, Robinson E, et al
This suggests that although metabolic disorders and hyperglycemia are major, their aftereffects are complex
Moreover, some drugs are associated with dose-limiting toxicities which limit their further utility
