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Neurobiol Aging 34: 2234.e912, 2013

[DOI] [PubMed] [Google Scholar] 264.Tang SM, Gabelaia L, Gauthier TW, Brown LAS

III Determination of the electrochemical properties of a soluble aqueous FeS species present in sulfidic solutions

Furthermore, beyond individual scaffold properties, general ADME/PK parameters such as pKa, pH-dependent ionization, and lipophilicity can influence binding orientation and promote ligand inversion, thereby favoring off-target activity
