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Oxidative stress can therefore precipitate the abnormalities induced by hyperglycemia and inflammation, mainly through the interaction with the polyol, hexosamine, angiotensin II pathways, the hyperactivation of protein kinase C isoforms (PKC) and the accumulation of advanced glycation end products (AGEs) (Wu MY

As an antioxidant, glutathione helps combat free radicalsunstable molecules that can cause cellular damage and contribute to chronic diseases

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It also can exert modulatory effects on the kynurenine pathway [141]