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this decrease resulted in reduced TCA cycle flux, leading to a decrease in precursors and energy for protein synthesis

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Med 344 , 10381042 (2001)

Developed in the laboratory of Joseph Harding at Washington State University as part of a program optimizing angiotensin-IV-derived neurotrophic peptides, Dihexa is approximately seven orders of magnitude (~10,000,000-fold) more potent than BDNF in inducing functional synaptogenesis between hippocampal neurons in vitro a figure that, even discounted aggressively, places it in a category of its own

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