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This is one of the main differences between AOD-9604 and full-length human growth hormone

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Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools

In the case of pronounced absorption disorders, for example as a result of gastritis or after removal of the small intestine, in Crohn's disease, diverticulosis and the so-called blind-loop syndrome, there is a gradual decrease in the vitamin B12 store in the liver, which can turn into a manifest vitamin B12 deficiency

The serine hydrolase ABHD6 is a critical regulator of the metabolic syndrome