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A growing body of preclinical research suggests that targeting the ferroptosis regulatory pathway centered on GPX4, including drug inhibitors, natural active compounds, gene or RNA intervention strategies, and novel local delivery systems, can alleviate cartilage degeneration and joint inflammation to varying degrees in experimental OA models

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doi: 10.1111/j.1365-2125.1986.tb02901.x

Such exchange reactions are rapid because they bypass the otherwise rate limiting step of release to the hydrated state

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