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Aside from generating both NADPH and ribose 5-phosphate, the PPP can operate four different modes where NADPH and/or ribose 5-phosphate is produced, depending on the cellular metabolic demands (Fig

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Similar to albumin, AAT can function as an indirect free radical scavenger by interacting with neutrophil alpha defensins, 159-161 free fatty acids, 162 and free heme

NADPH is one of the most important reducing agents in cells and protects from excess oxidative damage

Here, we hypothesize that GGCT, a potential endogenous source of cysteine other than xCT-mediated cystine uptake, may contribute to resistance to therapies involving xCT inhibition, such as erastin