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Pharmacological inhibition of glycolysis with 2-deoxyglucose reduced inflammatory signaling, posttraumatic hyperexcitability and epileptiform activity [66, 67]
Similar to the results previously shown, Klotho contributed to PI3K/AKT/FOXO3-related increase in MnSOD expression in Tac-injured HK-2 cells and mouse kidneys or rat renal IRI models 69,72
Thus, oral supplementation with VIC (1000 mg/day) was started, and after about 3 weeks, healthy granulation was observed, with a considerable reduction in the wound, which closed completely after almost 3 months
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